In addition to its antimycotic action, clotrimazole also acts on gram-positive microorganisms (Streptococci / Staphylococci / Gardnerella vaginalis), and gram-negative microorganisms (Bacteroides). In vitro activity is limited to proliferating fungal elements fungal spores are only slightly sensitive. The mode of action of clotrimazole is primarily fungistatic or fungicidal depending on the concentration of clotrimazole at the site of infection. Under appropriate test conditions, the MIC values for these types of fungi are in the region of less than 0.062-8.0 µg/ml substrate. Inhibition of ergosterol synthesis leads to structural and functional impairment of the fungal cytoplasmic membrane.Ĭlotrimazole has a broad antimycotic spectrum of action in vitro and in vivo, which includes dermatophytes, yeasts, moulds, etc. Pharmacotherapeutic group: Antifungals for topical use – imidazole and triazole derivativesĬlotrimazole acts against fungi by inhibiting ergosterol synthesis. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: or search for MHRA Yellow Card in the Google Play or Apple App Store. It allows continued monitoring of the benefit/risk balance of the medicinal product. Reporting suspected adverse reactions after authorisation of the medicinal product is important. General disorders and administration site conditions: application site irritation, application site reaction, oedema, pain. Skin and subcutaneous tissue disorders: blister, dermatitis contact, erythema, paraesthesia, skin exfoliation, pruritus, rash, urticaria, stinging skin/burning sensation skin. Respiratory, thoracic and mediastinal disorders: dyspnoea. Vascular disorders: syncope, hypotension. Immune system disorders: anaphylactic reaction, angioedema, hypersensitivity. Date of first authorisation/renewal of the authorisationĪs the listed undesirable effects are based on spontaneous reports, assigning accurate frequency of occurrence for each is not possible. 6.6 Special precautions for disposal and other handling.4.7 Effects on ability to drive and use machines.4.5 Interaction with other medicinal products and other forms of interaction.4.4 Special warnings and precautions for use.4.2 Posology and method of administration.Show table of contents Hide table of contents
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